Tag
Vitamin B12
12 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs12272669 | UNKNOWN | Intergenic variant on chromosome 11q13.4 associated with circulating vitamin ... | Appetite & Obesity | Emerging | |
| rs1801198 | TCN2 Pro259Arg (C776G) | Transcobalamin II variant affecting cellular delivery of vitamin B12 via holo... | Vitamins & Nutrient Absorption | Strong | |
| rs199971687 | MMAB | Pathogenic splice acceptor variant in MMAB that abolishes adenosylcobalamin s... | Vitamins & Nutrient Absorption | Established | |
| rs28941784 | MMAB Arg186Trp (R186W) | Missense variant eliminating MMAB adenosylcobalamin synthase activity; the mo... | Vitamins & Nutrient Absorption | Established | |
| rs369296618 | MMAB | Nonsense variant in MMAB creating a premature stop codon (Q234*) that impairs... | Vitamins & Nutrient Absorption | Established | |
| rs162036 | MTRR K350R (Lys350Arg) | MTRR cobalamin-reactivation variant — reduces B12 recycling efficiency and mo... | Methylation & Detox | Moderate | |
| rs5749131 | TCN2 | Upstream regulatory variant near TCN2 associated with reduced holotranscobala... | Vitamins & Nutrient Absorption | Moderate | |
| rs5753231 | TCN2 TCN2 2KB Upstream Variant | Promoter-proximal upstream variant in TCN2 that increases transcobalamin II p... | Vitamins & Nutrient Absorption | Emerging | |
| rs601338 | FUT2 W143X (Trp143Ter) | Determines secretor status — whether ABO blood group antigens are secreted in... | Vitamins & Nutrient Absorption | Established | |
| rs602662 | FUT2 Gly258Ser | Missense variant in the FUT2 fucosyltransferase enzyme that alters haptocorri... | Vitamins & Nutrient Absorption | Strong | |
| rs78060698 | FUT6 | Intronic regulatory variant in FUT6 that alters HNF4α binding and fucosyltran... | Vitamins & Nutrient Absorption | Moderate | |
| rs606231425 | MMACHC | Pathogenic missense variant in the cobalamin-processing enzyme; homozygosity ... | Methylation & Detox | Strong |