Tag
Smoking
9 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs1051730 | CHRNA3 Tyr215Tyr | CHRNA3 synonymous variant in the nicotinic receptor gene cluster strongly ass... | Mood & Behavior | Established | |
| rs16969968 | CHRNA5 Asp398Asn | Nicotinic receptor variant strongly associated with heavy smoking, nicotine d... | Mood & Behavior | Established | |
| rs2036527 | CHRNA5/CHRNA3 | Cis-regulatory enhancer variant at 15q25.1 that drives CHRNA3 and CHRNA5 expr... | Mood & Behavior | Strong | |
| rs1801272 | CYP2A6 *2 (L160H) | Loss-of-function CYP2A6 variant that abolishes nicotine metabolism, slowing c... | Pharmacogenomics | Established | |
| rs578776 | CHRNA3 3' UTR | CHRNA3 3' UTR variant at 15q25.1 Locus 2 — mechanistically distinct from rs10... | Mood & Behavior | Strong | |
| rs588765 | CHRNA5 5' UTR / Locus 3 | Intronic eQTL in CHRNA5 that modulates alpha-5 nicotinic receptor mRNA expres... | Mood & Behavior | Strong | |
| rs8034191 | AGPHD1/CHRNA3 15q25.1 intergenic | Intronic variant near CHRNA3 at 15q25.1 that acts as an eQTL for nicotinic re... | Mood & Behavior | Strong | |
| rs28399433 | CYP2A6 *9 (TATA box) | Promoter variant that reduces CYP2A6 expression by ~50%, slowing nicotine met... | Pharmacogenomics | Strong | |
| rs28399444 | CYP2A6 *7 (I471T) | CYP2A6*7 missense variant that nearly abolishes nicotine C-oxidase activity; ... | Pharmacogenomics | Established |