Tag
Skin
22 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs10794648 | IFNLR1/GRHL3 | Intergenic regulatory variant near IFNLR1 that contacts GRHL3 via chromatin l... | Interferon Signaling & Systemic Autoimmune | Moderate | |
| rs11652075 | CARD14 CARD14 Arg820Trp (R820W) | Missense variant in the keratinocyte NF-κB scaffold protein CARD14 that modes... | Psoriasis & Spondyloarthropathy | Strong | |
| rs12188300 | IL12B | Near-gene variant at the IL12B locus associated with psoriasis risk through a... | Psoriasis & Spondyloarthropathy | Moderate | |
| rs12191877 | HLA-C Tag for *06:02 | Tag SNP for HLA-C*06:02, the strongest genetic risk factor for psoriasis, det... | Psoriasis & Spondyloarthropathy | Established | |
| rs115161931 | CTSS | Independent CTSS-locus GWAS signal for atopic dermatitis on chromosome 1q21.3... | Allergy & Atopic Disease | Moderate | |
| rs17728338 | TNIP1 TNIP1/ABIN1 variant | Intergenic regulatory variant near TNIP1 whose A allele reduces ABIN1-mediate... | Psoriasis & Spondyloarthropathy | Strong | |
| rs2066808 | IL23A | Intronic variant near IL23A encoding the IL-23 p19 subunit; G allele increase... | Psoriasis & Spondyloarthropathy | Strong | |
| rs2256774 | IL2RA | Intronic IL2RA variant that modulates soluble IL-2RA shedding and Treg signal... | Autoimmune Tolerance & T-Cell Regulation | Moderate | |
| rs12123821 | FLG Filaggrin skin barrier variant | Common regulatory variant in the FLG locus associated with impaired skin barr... | Allergy & Atopic Disease | Strong | |
| rs3212227 | IL12B 3'UTR | IL12B 3'-UTR variant forming the canonical two-SNP psoriasis risk haplotype w... | Psoriasis & Spondyloarthropathy | Strong | |
| rs3213094 | IL12B Promoter-region | Intronic IL12B variant in linkage with the promoter-regulatory haplotype; T a... | Psoriasis & Spondyloarthropathy | Moderate | |
| rs3805435 | TNIP1 | Intronic variant in the GPX3/TNIP1 regulatory locus on chromosome 5; the C al... | Psoriasis & Spondyloarthropathy | Moderate | |
| rs610604 | TNFAIP3 | Intronic variant in TNFAIP3 whose G allele is the primary psoriasis susceptib... | Psoriasis & Spondyloarthropathy | Strong | |
| rs1420101 | IL1RL1 | Intronic regulatory variant in IL1RL1 that lowers soluble ST2 (sST2) decoy re... | Allergy & Atopic Disease | Strong | |
| rs61751629 | CARD14 Glu422Lys | Rare missense variant in the keratinocyte NF-κB scaffold protein CARD14 that ... | Psoriasis & Spondyloarthropathy | Emerging | |
| rs146527530 | CTSS CTSS AD Risk Signal (Budu-Aggrey 2023) | Third independent CTSS-locus atopic dermatitis risk signal from the Budu-Aggr... | Allergy & Atopic Disease | Moderate | |
| rs6887695 | IL12B Upstream regulatory | Upstream regulatory variant ~60 kb 5' of IL12B, forming the canonical two-SNP... | Psoriasis & Spondyloarthropathy | Strong | |
| rs7746808 | IL23A | Intergenic variant near the IL23A locus associated with psoriasis and psoriat... | Psoriasis & Spondyloarthropathy | Emerging | |
| rs187080438 | CTSS Cathepsin S antigen presentation variant | Intronic variant in the CTSS locus associated with elevated atopic dermatitis... | Allergy & Atopic Disease | Moderate | |
| rs2967677 | CERS4 Ceramide synthase 4 locus variant | A 3'UTR variant in the CERS4/NFILZ locus on chromosome 19 associated with ato... | Allergy & Atopic Disease | Strong | |
| rs7125552 | EMSY EMSY Haplotype Partner Allergy Variant | Intronic EMSY variant that defines the high-risk haplotype at 11q13.5; the G ... | Allergy & Atopic Disease | Moderate | |
| rs7927894 | EMSY | Regulatory variant near the EMSY/C11orf30 locus; T allele increases EMSY expr... | Allergy & Atopic Disease | Strong |