Tag
Obesity
100 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs10150332 | NRXN3 | Obesity and waist circumference GWAS hit in NRXN3 — links reward-circuit syna... | Appetite & Obesity | Strong | |
| rs10305420 | GLP1R Pro7Leu | GLP-1 receptor signal peptide variant that enhances semaglutide and tirzepati... | Pharmacogenomics | Moderate | |
| rs1042571 | POMC | 3'UTR variant in the appetite-suppression gene POMC that disrupts miRNA bindi... | Appetite & Obesity | Moderate | |
| rs10515237 | PCSK1 PCSK1 A/G (rs10515237) | Intronic variant in PCSK1 that tags the Q665E-S690T functional haplotype, red... | Appetite & Obesity | Moderate | |
| rs1064608 | MTCH2 Pro290Ala | Missense variant in MTCH2 that reduces mitochondrial metabolic efficiency, in... | Hormones & Sleep | Moderate | |
| rs1042044 | GLP1R Leu260Phe | GLP-1 receptor variant in intracellular loop 2 that alters receptor surface e... | Pharmacogenomics | Moderate | |
| rs10766383 | NUCB2 | Intronic NUCB2 variant associated with type 2 diabetes risk in females and or... | Hormones & Sleep | Moderate | |
| rs10767664 | BDNF | Obesity GWAS locus in a conserved BDNF enhancer - reduces hypothalamic BDNF e... | Appetite & Obesity | Strong | |
| rs1044498 | ENPP1 K121Q | ENPP1 K121Q variant that increases ENPP1 binding affinity to the insulin rece... | Blood Sugar & Diabetes | Strong | |
| rs10838738 | MTCH2 | Intronic GWAS obesity variant in MTCH2 — affects mitochondrial energy balance... | Appetite & Obesity | Moderate | |
| rs10852521 | FTO | FTO intron 1 variant associated with BMI and body fat accumulation, with stro... | Fitness & Body | Moderate | |
| rs10938397 | GNPDA2 | GIANT consortium GWAS obesity locus near GNPDA2 — affects hexosamine-pathway-... | Appetite & Obesity | Strong | |
| rs1776897 | HMGA1 | Chromatin remodeling variant near HMGA1 associated with waist-to-hip ratio an... | Liver Fat | Moderate | |
| rs10882283 | RBP4 RBP4 rs10882283 | 5' UTR variant in RBP4 that influences expression of retinol binding protein ... | Fat Storage & Energy | Moderate | |
| rs11037909 | EXT2 | Intronic EXT2 variant associated with a modest increase in type 2 diabetes su... | Appetite & Obesity | Moderate | |
| rs1108086 | FTO FTO Intron 8 T>C | An FTO intron-8 variant in the same haplotype block as rs1420318, with emergi... | Fitness & Body | Emerging | |
| rs1137101 | LEPR Q223R (Gln223Arg) | Common leptin receptor variant in the leptin-binding domain affecting satiety... | Hormones & Sleep | Moderate | |
| rs11152221 | MC4R MC4R Proximal LD Block Variant | Intergenic variant in the proximal 3' regulatory block near MC4R associated w... | Appetite & Obesity | Strong | |
| rs11644943 | FTO FTO Mid-Gene Intron Variant | An intronic FTO variant outside the well-known intron-1 obesity cluster; the ... | Appetite & Obesity | Emerging | |
| rs12970134 | MC4R MC4R region variant | Near-gene variant ~188kb downstream of MC4R associated with increased waist c... | Appetite & Obesity | Strong | |
| rs13407913 | ADCY3 | Intronic variant in the adenylyl cyclase 3 gene, which encodes a cAMP-produci... | Fitness & Body | Emerging | |
| rs1420318 | FTO | FTO intron 8 variant associated with nominal spine bone mineral density effec... | Fitness & Body | Emerging | |
| rs16147 | NPY C-399T | Promoter variant in neuropeptide Y that modulates NPY expression under stress... | Mood & Behavior | Moderate | |
| rs1175540 | PPARG PPARG rs1175540 | Intronic PPARG variant associated with differential weight loss response to c... | Fat Storage & Energy | Moderate | |
| rs17782313 | MC4R Near-gene C>T | Intergenic variant 188kb downstream of MC4R affecting appetite regulation, me... | Appetite & Obesity | Strong | |
| rs1330 | NUCB2 | Intronic NUCB2 variant associated with obesity risk in males, type 2 diabetes... | Hormones & Sleep | Moderate | |
| rs1800544 | ADRA2A ADRA2A Promoter -1291C>G | Promoter variant that alters alpha-2A adrenergic receptor expression, affecti... | Appetite & Obesity | Moderate | |
| rs1175544 | PPARG PPARG rs1175544 | Intronic PPARG variant that accounts for ~7% of individual variation in body ... | Fat Storage & Energy | Emerging | |
| rs1841499 | NEGR1 | Hypothalamic appetite regulator variant linking obesity susceptibility to mig... | Appetite & Obesity | Moderate | |
| rs12094543 | ZMYM4 ZMYM4 rs12094543 | Intronic variant in ZMYM4, a chromatin-remodeling transcription factor whose ... | Fat Storage & Energy | Emerging | |
| rs17219084 | FTO | FTO intron variant in the extended obesity-associated region, with explorator... | Fitness & Body | Emerging | |
| rs1943226 | MC4R MC4R third tagSNP | Upstream regulatory tag variant ~3 kb proximal to MC4R, included in MC4R hapl... | Appetite & Obesity | Emerging | |
| rs11705701 | IGF2BP2 IGF2BP2 Insulin Signaling Variant | Upstream regulatory variant in IGF2BP2 that shifts mRNA isoform balance in ad... | Blood Sugar & Diabetes | Moderate | |
| rs2229616 | MC4R V103I | Missense variant in MC4R converting valine to isoleucine at position 103; the... | Appetite & Obesity | Strong | |
| rs1554483 | CLOCK | Intronic CLOCK variant whose G allele, in a haplotype with rs4864548 A, confe... | Hormones & Sleep | Moderate | |
| rs2241423 | MAP2K5 | MAPK signaling variant in MAP2K5 associated with BMI through altered adipogen... | Appetite & Obesity | Moderate | |
| rs6536991 | UCP1 | Intronic UCP1 variant — the C allele is associated with reduced overweight ri... | Liver Fat | Emerging | |
| rs2815752 | NEGR1 | Top obesity GWAS variant near NEGR1 — affects hypothalamic appetite regulatio... | Appetite & Obesity | Strong | |
| rs2241766 | ADIPOQ T45G | Synonymous exon 2 variant in the adiponectin gene that affects mRNA stability... | Coronary Artery Disease & Atherosclerosis | Moderate | |
| rs2867125 | TMEM18 TMEM18 regulatory variant (2p25.3) | Regulatory variant at the TMEM18 locus on chromosome 2p25.3 — one of the most... | Appetite & Obesity | Strong | |
| rs2922126 | GHSR GHSR A/G (rs2922126) | Upstream regulatory variant near the ghrelin receptor gene; the A allele is a... | Appetite & Obesity | Moderate | |
| rs29941 | KCTD15 | GWAS obesity locus near KCTD15 — modulates adipogenesis through AP-2 transcri... | Appetite & Obesity | Moderate | |
| rs3827103 | MC3R | Common MC3R missense variant that reduces receptor expression and shifts nutr... | Appetite & Obesity | Moderate | |
| rs2568958 | NEGR1 NEGR1 depression/BMI variant | Intergenic tag SNP near NEGR1 associated with elevated BMI and major depressi... | Mood & Behavior | Strong | |
| rs476828 | MC4R MC4R-region BMI variant | Intergenic variant in the MC4R regulatory haplotype block, tagging the same a... | Appetite & Obesity | Strong | |
| rs17300539 | ADIPOQ -11391G>A | Promoter variant affecting adiponectin secretion and metabolic syndrome risk | Fat Storage & Energy | Strong | |
| rs4788102 | SH2B1 SH2B1/APOBR locus variant | Intronic variant at the SH2B1 locus on chromosome 16p11.2 — a key adaptor pro... | Appetite & Obesity | Strong | |
| rs1797912 | PPARG PPARG intronic haplotype variant | Intronic PPARG variant in the same haplotype block as rs1175543; the C allele... | Fat Storage & Energy | Emerging | |
| rs489693 | MC4R MC4R AIWG variant | Intergenic variant near MC4R with genome-wide significant association with an... | Appetite & Obesity | Strong | |
| rs1800592 | UCP1 A-3826G | Promoter variant reducing UCP1 expression in brown adipose tissue, impairing ... | Fat Storage & Energy | Moderate | |
| rs490683 | GHSR GHSR Promoter NF-1 Site Variant | Promoter variant in the ghrelin receptor gene that disrupts NF-1 transcriptio... | Appetite & Obesity | Moderate | |
| rs509035 | GHSR GHSR Metabolic Syndrome Variant | Intronic variant in the ghrelin receptor gene; the A allele is associated wit... | Appetite & Obesity | Strong | |
| rs1801282 | PPARG Pro12Ala | Insulin sensitivity - affects how well your cells respond to insulin | Fat Storage & Energy | Established | |
| rs571312 | MC4R MC4R Regulatory Variant (Appetite Signaling) | Regulatory variant upstream of MC4R associated with increased caloric intake,... | Appetite & Obesity | Strong | |
| rs6232 | PCSK1 PCSK1 N221D (Asn221Asp) | Missense variant in PCSK1 encoding an Asn221Asp substitution near the Ca-1 ca... | Appetite & Obesity | Strong | |
| rs6234 | PCSK1 PCSK1 Q665E (Gln665Glu) | Missense variant in PCSK1 that causes a Gln665Glu substitution in the C-termi... | Appetite & Obesity | Strong | |
| rs6235 | PCSK1 PCSK1 S690T (Ser690Thr) | Missense variant encoding the Ser690Thr substitution in the C-terminal domain... | Appetite & Obesity | Strong | |
| rs6548238 | TMEM18 | Second strongest obesity GWAS locus after FTO - influences hypothalamic appet... | Appetite & Obesity | Strong | |
| rs2304795 | PLIN1 | Synonymous exon 8 variant in perilipin 1 that tags a haplotype associated wit... | Fat Storage & Energy | Moderate | |
| rs6947337 | INHBA | Activin A signaling variant near INHBA linking adipocyte dysfunction to share... | Appetite & Obesity | Moderate | |
| rs2605100 | LYPLAL1 | Intronic variant in the LYPLAL1 locus associated with waist-hip ratio and fat... | Fat Storage & Energy | Strong | |
| rs696217 | GHRL Leu72Met | Missense variant in the ghrelin prepropeptide that impairs postprandial ghrel... | Appetite & Obesity | Moderate | |
| rs2287161 | CRY1 3' Downstream G>C | Cryptochrome 1 circadian gene variant influencing glucose metabolism, sleep t... | Hormones & Sleep | Strong | |
| rs2651899 | PRDM16 | Intronic variant in the master regulator of brown/beige fat differentiation, ... | Fat Storage & Energy | Moderate | |
| rs6905288 | VEGFA | Adipose tissue vascularization variant near VEGFA influencing fat distributio... | Vascular Inflammation & Remodeling | Moderate | |
| rs7359397 | SH2B1 SH2B1 C/T | Regulatory CpG-SNP downstream of SH2B1 that reduces gene expression via allel... | Appetite & Obesity | Moderate | |
| rs266729 | ADIPOQ -11391G>C | Promoter variant reducing adiponectin transcription, increasing T2D, NAFLD, a... | Fat Storage & Energy | Strong | |
| rs7498665 | SH2B1 Thr484Ala | Obesity GWAS missense variant in SH2B1 that impairs leptin signaling and incr... | Appetite & Obesity | Strong | |
| rs7566605 | INSIG2 | Upstream regulatory variant near INSIG2 that influences lipogenesis control a... | Appetite & Obesity | Moderate | |
| rs2920502 | PPARG PPARG rs2920502 | Intronic PPARG variant associated with body fat percentage, impaired glucose ... | Fat Storage & Energy | Moderate | |
| rs7647305 | ETV5 | GWAS obesity locus near ETV5 — affects hypothalamic appetite regulation and f... | Appetite & Obesity | Moderate | |
| rs2959272 | PPARG PPARG intronic calorie-restriction trial variant | Intronic PPARG variant significantly associated with individual variation in ... | Fat Storage & Energy | Emerging | |
| rs7799039 | LEP G-2548A | Promoter variant that increases leptin gene expression in adipose tissue, ele... | Appetite & Obesity | Moderate | |
| rs8087522 | MC4R MC4R A/G (rs8087522) | Upstream regulatory variant near MC4R that may create a transcription factor ... | Appetite & Obesity | Emerging | |
| rs62623713 | SYPL2 E99G | Low-frequency missense variant in SYPL2 associated with morbid obesity suscep... | Fitness & Body | Emerging | |
| rs9819506 | GHSR GHSR Promoter Variant (Ghrelin Receptor Signaling) | Promoter-region tag SNP in the ghrelin receptor gene associated with body wei... | Appetite & Obesity | Moderate | |
| rs3212018 | CD36 | A 16-bp deletion in the 3' untranslated region of CD36 that may reduce mRNA s... | Triglycerides & Fatty Acids | Emerging | |
| rs3745012 | LPIN2 LPIN2 3'UTR variant | 3' UTR regulatory variant in LPIN2 (lipin 2) that alters fat distribution and... | Fat Storage & Energy | Moderate | |
| rs987237 | TFAP2B | Adipocyte transcription factor variant influencing central fat distribution a... | Appetite & Obesity | Moderate | |
| rs9939609 | FTO Intron 1 T>A | The most strongly replicated obesity-associated variant, affecting body weigh... | Appetite & Obesity | Established | |
| rs2943641 | IRS1 Near-gene C>T | Regulates insulin signaling efficiency and cellular glucose uptake | Blood Sugar & Diabetes | Strong | |
| rs4684847 | PPARG PPARG cis-regulatory variant (PR domain recruitment) | Intronic cis-regulatory PPARG variant where the C allele recruits PR domain r... | Fat Storage & Energy | Moderate | |
| rs4684854 | PPARG | Intergenic regulatory variant downstream of PPARG associated with central obe... | Fat Storage & Energy | Emerging | |
| rs367643250 | DYRK1B R102C | Rare gain-of-function variant causing autosomal dominant metabolic syndrome (... | Blood Sugar & Diabetes | Strong | |
| rs4994 | ADRB3 Trp64Arg | Beta-3 adrenergic receptor variant that impairs catecholamine-stimulated lipo... | Fat Storage & Energy | Moderate | |
| rs3787348 | PTPN1 PTPN1 intronic variant | Intronic PTPN1 tag SNP within the 100-kb insulin-resistance haplotype block; ... | Blood Sugar & Diabetes | Moderate | |
| rs5181 | LRP8 Trp466Cys | Rare missense variant in the ApoE receptor 2 (LRP8) ligand-binding domain, di... | Fat Storage & Energy | Emerging | |
| rs660339 | UCP2 Ala55Val | Missense variant reducing mitochondrial uncoupling efficiency in white adipos... | Fat Storage & Energy | Moderate | |
| rs5082 | APOA2 -265T>C | Promoter variant that reduces APOA2 expression by 30%; GG homozygotes consumi... | Triglycerides & Fatty Acids | Strong | |
| rs5085 | APOA2 APOA2 rs5085 | Intronic APOA2 tag SNP that captures the saturated fat-weight gain interactio... | Triglycerides & Fatty Acids | Strong | |
| rs6954668 | SFRP5 SFRP5 Wnt5a inhibitor variant | Intergenic variant near the SFRP5 adipokine locus; the A allele is strongly e... | Fat Storage & Energy | Emerging | |
| rs3765467 | GLP1R Arg131Gln | Missense variant in the GLP-1 receptor that alters drug response to GLP-1 ago... | Pharmacogenomics | Moderate | |
| rs692383 | ABCG1 ABCG1 HDL-c Variant | Intronic variant in the ABCG1 cholesterol efflux transporter gene associated ... | Triglycerides & Fatty Acids | Emerging | |
| rs5443 | GNB3 C825T | Synonymous exon-10 variant that triggers alternative splicing of the G-protei... | Hormones & Sleep | Strong | |
| rs9491696 | RSPO3 | Intronic enhancer variant in RSPO3 that increases gene expression in adipocyt... | Fat Storage & Energy | Strong | |
| rs587777380 | DYRK1B H90P / H90R | Multi-allelic pathogenic locus — both H90P (T>G) and H90R (T>C) disrupt the D... | Blood Sugar & Diabetes | Strong | |
| rs757081 | NUCB2 Gln338Glu (Q338E) | Missense variant in nucleobindin-2, the precursor protein cleaved to produce ... | Hormones & Sleep | Moderate | |
| rs6067484 | PTPN1 PTPN1 rs6067484 | Intronic PTPN1 tag SNP within the 100-kb T2D-risk haplotype block — carriers ... | Blood Sugar & Diabetes | Moderate | |
| rs914458 | PTPN1 PTPN1 downstream variant | Downstream regulatory variant 10 kb 3' of PTPN1 (PTP1B) associated with type ... | Blood Sugar & Diabetes | Emerging | |
| rs6923761 | GLP1R Gly168Ser | GLP-1 receptor variant that alters response to GLP-1 agonist medications used... | Pharmacogenomics | Moderate |