Tag
Metabolic Health
78 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs10010131 | WFS1 WFS1 Intron 4 T2D Risk Variant | Intronic variant in WFS1 (wolframin) on chromosome 4q22, one of the earliest ... | Blood Sugar & Diabetes | Strong | |
| rs1044471 | ADIPOR2 ADIPOR2 3'UTR variant | A common 3'UTR variant in the liver-expressed adiponectin receptor 2 gene; th... | Fat Storage & Energy | Moderate | |
| rs1058322 | ADIPOR2 | Intronic ADIPOR2 variant whose T allele reduces receptor expression in immune... | Fat Storage & Energy | Moderate | |
| rs1059369 | GDF15 S48T | GDF15 signal-peptide missense variant that tags a haplotype influencing circu... | Fat Storage & Energy | Moderate | |
| rs1044498 | ENPP1 K121Q | ENPP1 K121Q variant that increases ENPP1 binding affinity to the insulin rece... | Blood Sugar & Diabetes | Strong | |
| rs10848554 | ADIPOR2 | Intronic ADIPOR2 variant co-associated with cardiovascular disease risk in in... | Fat Storage & Energy | Moderate | |
| rs11037909 | EXT2 | Intronic EXT2 variant associated with a modest increase in type 2 diabetes su... | Appetite & Obesity | Moderate | |
| rs11061937 | ADIPOR2 ADIPOR2 rs11061937 | Intronic ADIPOR2 variant associated with cardiovascular disease risk in indiv... | Fat Storage & Energy | Moderate | |
| rs11061946 | ADIPOR2 | Intronic variant in the adiponectin receptor 2 gene; rare homozygotes showed ... | Fat Storage & Energy | Emerging | |
| rs104894011 | GCK Glu265Lys (MODY2) | Pathogenic glucokinase missense variant causing MODY2 — mild, stable fasting ... | Blood Sugar & Diabetes | Established | |
| rs11644943 | FTO FTO Mid-Gene Intron Variant | An intronic FTO variant outside the well-known intron-1 obesity cluster; the ... | Appetite & Obesity | Emerging | |
| rs1151996 | PPARG PPARG rs1151996 | Intronic PPARG variant significantly associated with circulating vitamin D le... | Fat Storage & Energy | Moderate | |
| rs10885406 | TCF7L2 TCF7L2 Wnt Signaling Depth Variant | Intronic TCF7L2 variant tagging the diabetes-risk haplotype and associated wi... | Blood Sugar & Diabetes | Moderate | |
| rs116862713 | PRKAB1 | Rare AMPK beta-1 subunit variant linking central energy sensing to shared mig... | Fat Storage & Energy | Emerging | |
| rs10954640 | ENPP1 ENPP1 3'UTR Variant | Intergenic variant near ENPP1-associated regulatory loci; T allele is associa... | Blood Sugar & Diabetes | Emerging | |
| rs1175543 | PPARG PPARG rs1175543 | Intronic PPARG variant in strong linkage disequilibrium with rs709158; the G ... | Fat Storage & Energy | Emerging | |
| rs1330 | NUCB2 | Intronic NUCB2 variant associated with obesity risk in males, type 2 diabetes... | Hormones & Sleep | Moderate | |
| rs1175544 | PPARG PPARG rs1175544 | Intronic PPARG variant that accounts for ~7% of individual variation in body ... | Fat Storage & Energy | Emerging | |
| rs563694 | ABCB11 G6PC2/ABCB11 fasting glucose locus | Intronic variant in ABCB11 in strong linkage disequilibrium with G6PC2 regula... | Liver Fat | Strong | |
| rs11558471 | SLC30A8 SLC30A8 Zinc Transport Depth Variant | 3-prime UTR variant in the SLC30A8 zinc transporter gene that alters ZnT8 mRN... | Blood Sugar & Diabetes | Strong | |
| rs184660829 | DENND2C | Rare intronic variant near a DENND2C splice site associated with an 8-fold in... | Appetite & Obesity | Moderate | |
| rs12304921 | SLC11A2 | Intronic variant in SLC11A2 (DMT1), the primary intestinal iron transporter, ... | Fat Storage & Energy | Emerging | |
| rs2229616 | MC4R V103I | Missense variant in MC4R converting valine to isoleucine at position 103; the... | Appetite & Obesity | Strong | |
| rs11708067 | ADCY5 ADCY5 Glucose Signaling Variant | Intronic regulatory variant that reduces ADCY5 expression in pancreatic islet... | Blood Sugar & Diabetes | Strong | |
| rs12490265 | PPARG PPARG Intronic Haplotype Variant | Intronic PPARG variant in a metabolic syndrome–associated haplotype block; th... | Fat Storage & Energy | Emerging | |
| rs17493811 | AGER | Tag SNP in the AGER 3′ downstream region associated with increased type 1 dia... | Hormones & Sleep | Moderate | |
| rs16861194 | ADIPOQ -11426A>G | Upstream promoter variant that reduces ADIPOQ transcription, lowering circula... | Fat Storage & Energy | Moderate | |
| rs2922126 | GHSR GHSR A/G (rs2922126) | Upstream regulatory variant near the ghrelin receptor gene; the A allele is a... | Appetite & Obesity | Moderate | |
| rs16861205 | ADIPOQ | Intronic ADIPOQ variant in LD with the promoter region; the minor A allele is... | Fat Storage & Energy | Moderate | |
| rs2361502 | MROH2A | Intronic variant adjacent to the UGT1A gene cluster; C allele tags elevated s... | Metabolic Enzymes & Rare Disorders | Moderate | |
| rs4784165 | TOX3 TOX3 rs4784165 | Intronic PCOS susceptibility variant near TOX3; the G allele is associated wi... | Fertility & Ovarian Function | Moderate | |
| rs16928751 | ADIPOR2 ADIPOR2 CVD co-association variant | Synonymous coding variant in ADIPOR2 (Q265Q) that was co-associated with card... | Fat Storage & Energy | Emerging | |
| rs1402837 | G6PC2 G6PC2 Fasting Glucose Variant | Upstream regulatory variant in G6PC2 that modulates pancreatic beta-cell gluc... | Blood Sugar & Diabetes | Strong | |
| rs1495377 | TSPAN8 | Intronic variant in TSPAN8 (Tetraspanin 8) associated with reduced insulin se... | Blood Sugar & Diabetes | Strong | |
| rs1797912 | PPARG PPARG intronic haplotype variant | Intronic PPARG variant in the same haplotype block as rs1175543; the C allele... | Fat Storage & Energy | Emerging | |
| rs1884614 | HNF4A HNF4A P2 Promoter rs1884614 | Intronic variant tagging the HNF4A P2 promoter risk haplotype; the T allele i... | Hormones & Sleep | Moderate | |
| rs1991517 | TSHR Asp727Glu | Affects TSH receptor sensitivity and thyroid hormone regulation; influences T... | Hormones & Sleep | Strong | |
| rs490683 | GHSR GHSR Promoter NF-1 Site Variant | Promoter variant in the ghrelin receptor gene that disrupts NF-1 transcriptio... | Appetite & Obesity | Moderate | |
| rs1562444 | MTNR1B MTNR1B 3'UTR Melatonin Signaling Variant | Regulatory 3'UTR variant in the melatonin receptor 1B gene that affects MTNR1... | Blood Sugar & Diabetes | Moderate | |
| rs2016105 | ELK3 ELK3 TSH regulatory variant | Intronic regulatory variant in ELK3 influencing circulating TSH levels and hy... | Hormones & Sleep | Strong | |
| rs509035 | GHSR GHSR Metabolic Syndrome Variant | Intronic variant in the ghrelin receptor gene; the A allele is associated wit... | Appetite & Obesity | Strong | |
| rs1571583 | GLIS3 GLIS3 Beta Cell Development Variant | Intronic GLIS3 variant in which the rare A allele modestly elevates TSH, refl... | Blood Sugar & Diabetes | Strong | |
| rs16989673 | PTPN1 1484insG | A guanine duplication in the 3'-UTR of PTPN1 (PTP1B) that increases mRNA stab... | Blood Sugar & Diabetes | Moderate | |
| rs17696736 | NAA25 NAA25 G/A | Intronic tag SNP at the 12q24 locus that captures SH2B3/LNK regulatory variat... | Blood Sugar & Diabetes | Strong | |
| rs2144908 | HNF4A HNF4A P2 Block rs2144908 | Intronic HNF4A P2 promoter haplotype tag variant; carriers have modestly impa... | Hormones & Sleep | Moderate | |
| rs6947337 | INHBA | Activin A signaling variant near INHBA linking adipocyte dysfunction to share... | Appetite & Obesity | Moderate | |
| rs1884613 | HNF4A HNF4A P2 Promoter T2D Variant | Intronic variant tagging the HNF4A P2 promoter risk haplotype; the G allele s... | Blood Sugar & Diabetes | Moderate | |
| rs193922485 | HNF1B | Rare HNF1B splice-region intronic variant of uncertain significance, found ne... | Blood Sugar & Diabetes | Emerging | |
| rs2229431 | INSR | Synonymous exon 13 variant in the insulin receptor gene; the A allele has bee... | Blood Sugar & Diabetes | Emerging | |
| rs2959272 | PPARG PPARG intronic calorie-restriction trial variant | Intronic PPARG variant significantly associated with individual variation in ... | Fat Storage & Energy | Emerging | |
| rs2237886 | KCNQ1 KCNQ1 Potassium Channel Diabetes Variant | Intronic variant in KCNQ1's imprinted region, tagging the same LD block as es... | Blood Sugar & Diabetes | Moderate | |
| rs358806 | WNT5A | Regulatory variant near WNT5A linked to type 2 diabetes risk via impaired Wnt... | Fat Storage & Energy | Moderate | |
| rs2268574 | GCK c.679+38T>G | Intronic GCK variant 38 bp downstream of exon 7; the A allele (GRCh38 referen... | Blood Sugar & Diabetes | Emerging | |
| rs9819506 | GHSR GHSR Promoter Variant (Ghrelin Receptor Signaling) | Promoter-region tag SNP in the ghrelin receptor gene associated with body wei... | Appetite & Obesity | Moderate | |
| rs2466293 | SLC30A8 SLC30A8 Islet Zinc Regulation Variant | 3'UTR variant in the zinc transporter ZnT8 gene that disrupts miRNA binding s... | Blood Sugar & Diabetes | Moderate | |
| rs290475 | TCF7L2 TCF7L2 Beta Cell Function Depth Variant | Intronic TCF7L2 variant tagging a distinct haplotype with emerging evidence f... | Blood Sugar & Diabetes | Emerging | |
| rs3856806 | PPARG His477His (C1431T) | Synonymous PPARG variant where the T allele reduces type 2 diabetes risk and ... | Fat Storage & Energy | Strong | |
| rs4684847 | PPARG PPARG cis-regulatory variant (PR domain recruitment) | Intronic cis-regulatory PPARG variant where the C allele recruits PR domain r... | Fat Storage & Energy | Moderate | |
| rs4684854 | PPARG | Intergenic regulatory variant downstream of PPARG associated with central obe... | Fat Storage & Energy | Emerging | |
| rs4810424 | R3HDML R3HDML rs4810424 | Intronic variant tagging the HNF4A P2 promoter risk haplotype; C allele carri... | Fat Storage & Energy | Moderate | |
| rs3787345 | PTPN1 PTPN1 LD Block Co-Variant | Intronic PTPN1 tag SNP within the 100-kb PTP1B insulin-resistance haplotype b... | Blood Sugar & Diabetes | Moderate | |
| rs3787348 | PTPN1 PTPN1 intronic variant | Intronic PTPN1 tag SNP within the 100-kb insulin-resistance haplotype block; ... | Blood Sugar & Diabetes | Moderate | |
| rs397514580 | GCK GCK MODY2 E339K | Pathogenic glucokinase missense variant causing maturity-onset diabetes of th... | Blood Sugar & Diabetes | Strong | |
| rs4607517 | GCK GCK fasting glucose GWAS variant | Common intronic variant near glucokinase that raises fasting glucose by impai... | Blood Sugar & Diabetes | Strong | |
| rs6954668 | SFRP5 SFRP5 Wnt5a inhibitor variant | Intergenic variant near the SFRP5 adipokine locus; the A allele is strongly e... | Fat Storage & Energy | Emerging | |
| rs4807015 | PTPRS PTPRS T2D risk variant | Intronic PTPRS variant that tags elevated type 2 diabetes risk in both sexes ... | Blood Sugar & Diabetes | Moderate | |
| rs4812829 | HNF4A HNF4A Intronic T2D Risk Variant | Common intronic variant in HNF4A associated with modestly elevated type 2 dia... | Blood Sugar & Diabetes | Strong | |
| rs709158 | PPARG | Intronic PPARG variant in strong linkage disequilibrium with rs1175543; the G... | Fat Storage & Energy | Emerging | |
| rs492594 | G6PC2 Val219Leu | Coding variant in the islet glucose-6-phosphatase that fine-tunes the fasting... | Blood Sugar & Diabetes | Moderate | |
| rs822391 | ADIPOQ IVS1+407C>T | Intronic variant in the adiponectin gene associated with circulating adiponec... | Fat Storage & Energy | Moderate | |
| rs6020611 | PTPN1 | Intronic PTPN1 tag SNP in the PTP1B regulatory LD block; the minor A allele i... | Blood Sugar & Diabetes | Moderate | |
| rs743572 | CYP17A1 -34 T>C | Promoter variant affecting 17α-hydroxylase expression and steroid hormone syn... | Hormones & Sleep | Strong | |
| rs6031551 | HNF4A HNF4A Regulatory Variant | Intronic variant 80 bp from rs6031552 within the HNF4A P2 promoter haplotype ... | Blood Sugar & Diabetes | Emerging | |
| rs6031552 | HNF4A HNF4A Regulatory Variant | Intronic variant tagging the HNF4A P2 promoter haplotype; carriers have modes... | Blood Sugar & Diabetes | Moderate | |
| rs6067484 | PTPN1 PTPN1 rs6067484 | Intronic PTPN1 tag SNP within the 100-kb T2D-risk haplotype block — carriers ... | Blood Sugar & Diabetes | Moderate | |
| rs7850258 | PTCSC2 | Intronic variant in the PTCSC2 lncRNA that alters a FOXE1 enhancer element, m... | Hormones & Sleep | Strong | |
| rs7202877 | CTRB1 | Intergenic variant near CTRB1/CTRB2 that regulates chymotrypsinogen expressio... | Blood Sugar & Diabetes | Strong | |
| rs965513 | FOXE1 | Strongest GWAS thyroid locus — regulatory variant near FOXE1 affecting thyroi... | Hormones & Sleep | Strong |