Tag
Mental Health
44 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs1006737 | CACNA1C | L-type calcium channel gene variant affecting mood regulation, emotional proc... | Mood & Behavior | Strong | |
| rs10514299 | TMEM161B-MEF2C TMEM161B-MEF2C intergenic variant | Intronic variant near the MEF2C transcription factor locus associated with in... | Mood & Behavior | Strong | |
| rs1051730 | CHRNA3 Tyr215Tyr | CHRNA3 synonymous variant in the nicotinic receptor gene cluster strongly ass... | Mood & Behavior | Established | |
| rs10947690 | MDGA1 Leu61Pro | Missense variant in the inhibitory synapse regulator MDGA1 that impairs neuro... | Hormones & Sleep | Strong | |
| rs1058164 | CYP2D6 | Synonymous CYP2D6 variant that promotes exon 3 skipping, reducing functional ... | Pharmacogenomics | Moderate | |
| rs12624433 | SLC12A5 KCC2 Chloride Transport | Intronic variant in SLC12A5 reducing KCC2 potassium-chloride cotransporter fu... | Mood & Behavior | Moderate | |
| rs1064395 | NCAN | 3' UTR variant in the neurocan gene associated with bipolar disorder and schi... | Neurology & Cognition | Strong | |
| rs1387923 | NTRK2 NTRK2/TrkB 3'UTR variant | 3' UTR variant in the TrkB receptor gene affecting NTRK2 expression; associat... | Mood & Behavior | Moderate | |
| rs1545843 | SLC6A15 SLC6A15 depression risk variant | Intronic variant reducing SLC6A15 expression in hippocampus; AA carriers show... | Mood & Behavior | Strong | |
| rs12696304 | TERC | Regulatory variant near the telomerase RNA gene associated with shorter telom... | Longevity & Aging | Established | |
| rs16969968 | CHRNA5 Asp398Asn | Nicotinic receptor variant strongly associated with heavy smoking, nicotine d... | Mood & Behavior | Established | |
| rs16847897 | TERC | Regulatory variant at the TERC locus associated with shorter telomeres and ac... | Longevity & Aging | Strong | |
| rs1800883 | HTR5A | Promoter/5' UTR variant in the serotonin 5-HT5A receptor gene affecting recep... | Mood & Behavior | Moderate | |
| rs2036527 | CHRNA5/CHRNA3 | Cis-regulatory enhancer variant at 15q25.1 that drives CHRNA3 and CHRNA5 expr... | Mood & Behavior | Strong | |
| rs2522833 | PCLO Ser4814Ala | Missense variant in the C2A calcium-binding domain of presynaptic scaffolding... | Mood & Behavior | Moderate | |
| rs25531 | SLC6A4 A>G | Promoter SNP near 5-HTTLPR that modifies serotonin transporter expression and... | Mood & Behavior | Moderate | |
| rs184039278 | CRY1 CRY1Δ11 | Splice-site variant in the circadian clock gene CRY1 that causes exon 11 skip... | Hormones & Sleep | Strong | |
| rs279858 | GABRA2 K132K | GABA-A receptor alpha-2 subunit variant affecting alcohol response, anxiety, ... | Mood & Behavior | Strong | |
| rs324420 | FAAH Pro129Thr | Affects anandamide levels through altered FAAH enzyme stability, influencing ... | Mood & Behavior | Strong | |
| rs35936514 | LHPP LHPP depression risk variant | Intronic/3'UTR variant in LHPP, a histidine phosphatase essential for stress ... | Mood & Behavior | Strong | |
| rs41423247 | NR3C1 BclI | Intronic glucocorticoid receptor variant affecting cortisol sensitivity and s... | Mood & Behavior | Strong | |
| rs1718119 | P2RX7 Ala348Thr | Gain-of-function variant in the P2X7 receptor that increases ATP-gated pore f... | Neurology & Cognition | Moderate | |
| rs4395923 | CYP7B1 CYP7B1 Neurosteroid Hydroxylase | Intronic variant in the brain neurosteroid hydroxylase gene affecting DHEA an... | Mood & Behavior | Emerging | |
| rs4570625 | TPH2 G-703T | Promoter variant affecting brain serotonin synthesis enzyme; influences emoti... | Mood & Behavior | Moderate | |
| rs2736100 | TERT | Common intron 2 variant in the telomerase gene that influences telomere lengt... | Longevity & Aging | Strong | |
| rs578776 | CHRNA3 3' UTR | CHRNA3 3' UTR variant at 15q25.1 Locus 2 — mechanistically distinct from rs10... | Mood & Behavior | Strong | |
| rs588765 | CHRNA5 5' UTR / Locus 3 | Intronic eQTL in CHRNA5 that modulates alpha-5 nicotinic receptor mRNA expres... | Mood & Behavior | Strong | |
| rs6295 | HTR1A C-1019G | Functional promoter variant in the serotonin 1A receptor gene that increases ... | Mood & Behavior | Strong | |
| rs6311 | HTR2A -1438G>A | Regulatory variant in serotonin 2A receptor gene affecting SSRI side effects ... | Mood & Behavior | Moderate | |
| rs6323 | MAOA R297R | X-linked monoamine oxidase A variant affecting enzyme activity and neurotrans... | Mood & Behavior | Strong | |
| rs2229431 | INSR | Synonymous exon 13 variant in the insulin receptor gene; the A allele has bee... | Blood Sugar & Diabetes | Emerging | |
| rs73034295 | IGSF9B IGSF9B Inhibitory Synapse Adhesion | Intronic variant in the gene encoding the inhibitory synaptic adhesion protei... | Mood & Behavior | Emerging | |
| rs208294 | P2RX7 His155Tyr | Gain-of-function missense variant in the P2X7 ATP-gated receptor that increas... | Neurology & Cognition | Moderate | |
| rs8034191 | AGPHD1/CHRNA3 15q25.1 intergenic | Intronic variant near CHRNA3 at 15q25.1 that acts as an eQTL for nicotinic re... | Mood & Behavior | Strong | |
| rs2230912 | P2RX7 Gln460Arg | Missense variant in the C-terminal domain of the P2X7 receptor that disrupts ... | Neurology & Cognition | Moderate | |
| rs956572 | BCL2 | Intronic variant in the anti-apoptotic gene BCL2 that affects BCL2 expression... | Mood & Behavior | Moderate | |
| rs6198 | NR3C1 9β | 3'UTR variant that increases glucocorticoid-resistant GRβ isoform expression,... | Longevity & Aging | Strong | |
| rs4307059 | CDH9/CDH10 | Intergenic variant at 5p14.1 between neuronal cell-adhesion genes CDH9 and CD... | Hormones & Sleep | Strong | |
| rs7895833 | SIRT1 A>G | Intronic variant in SIRT1 affecting NAD-dependent deacetylase expression and ... | Longevity & Aging | Moderate | |
| rs9536314 | KLOTHO F352V (KL-VS) | Longevity-associated variant exhibiting overdominance where heterozygotes sho... | Longevity & Aging | Strong | |
| rs55694368 | PER2 PER2 regulatory variant | Upstream regulatory signal near the core circadian clock gene PER2 that shift... | Hormones & Sleep | Strong | |
| rs4680 | COMT Val158Met | Dopamine/catecholamine breakdown — affects stress response and methyl donor t... | Methylation & Detox | Established | |
| rs72547511 | CYP1A2 CYP1A2*15 (Pro42Arg) | Rare CYP1A2 missense variant at the critical Pro42 position; nearly abolishes... | Pharmacogenomics | Moderate | |
| rs72549354 | CYP2D6 *20 | Frameshift insertion creating a null CYP2D6 allele; carriers cannot metaboliz... | Pharmacogenomics | Established |