Tag
Interferon
33 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs10181656 | STAT4 | Intronic STAT4 tagging SNP on the primary SLE risk haplotype; the sentinel va... | Interferon Signaling & Systemic Autoimmune | Strong | |
| rs10488631 | IRF5 | Near-gene regulatory variant tagging an IRF5 haplotype that elevates interfer... | Interferon Signaling & Systemic Autoimmune | Strong | |
| rs10794648 | IFNLR1/GRHL3 | Intergenic regulatory variant near IFNLR1 that contacts GRHL3 via chromatin l... | Interferon Signaling & Systemic Autoimmune | Moderate | |
| rs10954213 | IRF5 3'UTR polyadenylation | 3'UTR variant creating a functional polyadenylation site; A allele produces a... | Interferon Signaling & Systemic Autoimmune | Strong | |
| rs11269962 | IRF5 Regulatory | A 14-bp indel 2.2 kb upstream of IRF5 that is the most strongly associated ci... | Interferon Signaling & Systemic Autoimmune | Moderate | |
| rs12720270 | TYK2 TYK2 Intron 7 Splicing Variant | An intronic variant in TYK2 intron 7 that promotes exon 8 inclusion in the ma... | Autoimmune Tolerance & T-Cell Regulation | Moderate | |
| rs12720356 | TYK2 Ile684Ser | A missense variant in the TYK2 pseudokinase (JH2) domain that partially impai... | Autoimmune Tolerance & T-Cell Regulation | Strong | |
| rs13245639 | IRF5 Regulatory | Cis-regulatory IRF5 variant in near-perfect LD (r²=0.97) with the rs729302 pr... | Interferon Signaling & Systemic Autoimmune | Moderate | |
| rs12252 | IFITM3 IFITM3 rs12252 (c.42T>C) | Splice-region synonymous variant in the innate antiviral gene IFITM3; the G a... | Innate Immunity & Infection Defense | Strong | |
| rs1861494 | IFNG IFNG Interferon Gamma | Intronic IFNG variant that modulates interferon-gamma expression, with the T ... | Interferon Signaling & Systemic Autoimmune | Moderate | |
| rs1539243 | IKBKE IKBKE Ile67 synonymous variant | Synonymous coding variant in exon 4 of IKBKE (IKK-epsilon); the C allele tags... | Psoriasis & Spondyloarthropathy | Moderate | |
| rs1990760 | IFIH1 Ala946Thr | Gain-of-function missense variant in the MDA5 viral RNA sensor, enhancing typ... | Interferon Signaling & Systemic Autoimmune | Strong | |
| rs2004640 | IRF5 G198T | Intronic variant creating alternative splice site that increases type I inter... | Interferon Signaling & Systemic Autoimmune | Strong | |
| rs117648444 | IFNL4 Pro70Ser (P70S) | Missense variant in IFNL4 exon 2 that reduces IFN-λ4 protein activity; the Se... | Pharmacogenomics | Strong | |
| rs2234067 | ETV7 ETV7 rs2234067 | Upstream regulatory variant near ETV7, an interferon-inducible transcriptiona... | Interferon Signaling & Systemic Autoimmune | Strong | |
| rs2280714 | IRF5 3'UTR | Downstream regulatory variant in the IRF5 3' region that elevates IRF5 mRNA e... | Interferon Signaling & Systemic Autoimmune | Moderate | |
| rs12979860 | IFNL4 | Intronic variant in IFNL4 — the strongest host genetic predictor of hepatitis... | Pharmacogenomics | Established | |
| rs2304256 | TYK2 TYK2 V362F | A common missense and splicing variant in TYK2 that promotes exon 8 inclusion... | Autoimmune Tolerance & T-Cell Regulation | Strong | |
| rs12980275 | IFNL3 | Downstream variant near IFNL3 — third IL28B locus predictor of hepatitis C sp... | Pharmacogenomics | Established | |
| rs3131379 | MSH5 | Intronic variant in the HLA class III region near MSH5 associated with lupus ... | Interferon Signaling & Systemic Autoimmune | Strong | |
| rs4728142 | IRF5 Promoter Indel Tag (CGGGG insertion) | Enhancer variant ~5 kb upstream of IRF5 that promotes ZBTB3-mediated chromati... | Interferon Signaling & Systemic Autoimmune | Strong | |
| rs729302 | IRF5 | Near-gene variant tagging an IRF5 protective haplotype in the 5' promoter reg... | Interferon Signaling & Systemic Autoimmune | Strong | |
| rs41298997 | IKBKE | Intronic variant in IKBKE (IKK-epsilon) associated with psoriasis susceptibil... | Psoriasis & Spondyloarthropathy | Moderate | |
| rs35018800 | TYK2 TYK2 Ala928Val | A rare missense variant in the TYK2 pseudokinase (JH2) domain that partially ... | Autoimmune Tolerance & T-Cell Regulation | Strong | |
| rs7574865 | STAT4 Intron 3 | Intronic STAT4 variant that amplifies the interferon-alpha and IL-12 response... | Interferon Signaling & Systemic Autoimmune | Strong | |
| rs9378815 | IRF4 | Regulatory variant ~15 kb upstream of IRF4 that modulates germinal center B c... | Interferon Signaling & Systemic Autoimmune | Strong | |
| rs7540214 | IFNLR1 IFNLR1 variant | Intronic variant in the interferon lambda receptor 1 gene that elevates PsA r... | Psoriasis & Spondyloarthropathy | Moderate | |
| rs7047299 | IFNA21 | Regulatory variant upstream of interferon alpha-21 associated with increased ... | Innate Immunity & Infection Defense | Moderate | |
| rs34536443 | TYK2 TYK2 p.Pro1104Ala | A missense variant in TYK2 that partially impairs JAK-family signaling downst... | Hormones & Sleep | Strong | |
| rs2069705 | IFNG IFNG Promoter -1616C/T | Upstream regulatory variant ~1,616 bp before the IFNG transcription start sit... | Allergy & Atopic Disease | Moderate | |
| rs368234815 | IFNL4 ss469415590 (TT/ΔG) | Causal frameshift polymorphism controlling IFNL4 protein production; the ΔG a... | Pharmacogenomics | Established | |
| rs4803217 | IFNL3 3'UTR | 3' untranslated region variant in IFNL3 (IL28B) that controls mRNA stability ... | Pharmacogenomics | Strong | |
| rs8099917 | IFNL3 | Intergenic variant upstream of IFNL3 — second major IL28B locus predictor of ... | Pharmacogenomics | Established |