Tag
Double-Strand Break Repair
9 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs17879961 | CHEK2 I157T | Missense variant in the CHEK2 FHA domain that impairs phosphoprotein binding ... | Cancer Risk | Strong | |
| rs12651246 | HELQ HELQ Helicase Meiotic Repair Variant | An intronic variant in HELQ (helicase, POLQ-like) on chromosome 4q21.23; the ... | Gamete Quality & DNA Repair | Strong | |
| rs1805362 | MRE11 | Missense variant in MRE11 (p.Met698Val, T>C on plus strand) at a poorly conse... | Gamete Quality & DNA Repair | Moderate | |
| rs1805794 | NBN E185Q | Component of the MRN complex essential for DNA double-strand break repair, te... | Cancer Risk | Strong | |
| rs236114 | MCM8 | Intronic variant in MCM8 (minichromosome maintenance 8 helicase) on chromosom... | Gamete Quality & DNA Repair | Strong | |
| rs353478 | UIMC1 UIMC1 DNA Damage Response Variant | An intronic variant in UIMC1 (RAP80), the core ubiquitin-binding subunit of t... | Gamete Quality & DNA Repair | Strong | |
| rs555607708 | CHEK2 1100delC | Frameshift deletion in the CHEK2 checkpoint kinase that abolishes kinase acti... | Cancer Risk | Established | |
| rs1950897 | RAD51B RAD51B Intronic RA Susceptibility Variant | Intronic variant in RAD51B on chromosome 14; the T allele is associated with ... | Allergy & Atopic Disease | Strong | |
| rs963917 | RAD51B RAD51B Central European RA Variant | A 3' UTR variant in RAD51B that alters miRNA-616 binding efficiency and is as... | Allergy & Atopic Disease | Emerging |