Tag
Detoxification
50 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs1001179 | CAT -262C>T | Catalase promoter variant affecting hydrogen peroxide clearance and antioxida... | Methylation & Detox | Strong | |
| rs10156191 | AOC1 Thr16Met | DAO structural variant affecting enzyme activity and histamine degradation | Methylation & Detox | Strong | |
| rs1048943 | CYP1A1 Ile462Val (*2C) | Phase I detoxification enzyme that activates polycyclic aromatic hydrocarbons... | Methylation & Detox | Strong | |
| rs1049742 | AOC1 | Missense variant in the diamine oxidase enzyme that contributes to reduced hi... | Methylation & Detox | Moderate | |
| rs1049793 | AOC1 His645Asp | DAO structural variant near the catalytic domain affecting histamine degradation | Methylation & Detox | Strong | |
| rs1229984 | ADH1B His48Arg | ADH1B variant encoding a ~100x faster alcohol dehydrogenase enzyme, causing r... | Mood & Behavior | Established | |
| rs1050450 | GPX1 Pro198Leu | Selenium-dependent antioxidant enzyme that neutralizes hydrogen peroxide; the... | Methylation & Detox | Strong | |
| rs2032582 | ABCB1 G2677T/A (Ser893Ala/Thr) | Triallelic missense variant in the P-glycoprotein efflux pump that reduces th... | Gamete Quality & DNA Repair | Moderate | |
| rs1050891 | HNMT 3'UTR variant | Histamine breakdown in blood and tissues - uses methyl groups from SAM | Methylation & Detox | Moderate | |
| rs1799750 | MMP1 1G/2G | Promoter polymorphism affecting MMP1 expression and collagen degradation rate... | Skin & Eyes | Strong | |
| rs4646903 | CYP1A1 *2A (MspI, T3801C) | Regulatory variant in the 3'-flanking region of CYP1A1 that increases gene in... | Dental & Oral Health | Moderate | |
| rs1056836 | CYP1B1 Leu432Val | Phase I detoxification enzyme that hydroxylates estradiol to potentially geno... | Methylation & Detox | Moderate | |
| rs13181 | ERCC2 Lys751Gln | Missense variant in the XPD helicase that reduces nucleotide excision repair ... | Longevity & Aging | Strong | |
| rs1693482 | ADH1C Arg272Gln (ADH1C*1/*2) | ADH1C variant defining the fast (ADH1C*1, Arg272) vs slow (ADH1C*2, Gln272) a... | Mood & Behavior | Strong | |
| rs2470890 | CYP1A2 Asn516= (exon 7) | Synonymous variant in CYP1A2 exon 7 in linkage disequilibrium with the *1F hi... | Cancer Risk | Strong | |
| rs1138272 | GSTP1 Ala114Val | Second functional variant in glutathione S-transferase Pi 1, reducing enzyme ... | Methylation & Detox | Moderate | |
| rs11545076 | GGH -124T>G | Promoter variant that increases GGH expression, accelerating hydrolysis of in... | Methylation & Detox | Moderate | |
| rs11558538 | HNMT Thr105Ile | HNMT structural variant - reduces enzyme stability and histamine clearance in... | Methylation & Detox | Strong | |
| rs234709 | CBS | Intronic CBS variant that tags the CBS locus in GWAS studies; associated with... | Vitamins & Nutrient Absorption | Moderate | |
| rs2066702 | ADH1B Arg370Cys | ADH1B*3 variant encoding a superactive alcohol dehydrogenase found almost exc... | Mood & Behavior | Strong | |
| rs1208 | NAT2 R268K | NAT2 acetylation speed tag SNP - marks rapid vs slow acetylator haplotypes | Methylation & Detox | Established | |
| rs28929474 | SERPINA1 Z allele (E342K) | Most common alpha-1 antitrypsin deficiency variant causing protein misfolding... | Metabolic Enzymes & Rare Disorders | Established | |
| rs1695 | GSTP1 Ile105Val | Phase II detoxification enzyme that conjugates glutathione to carcinogens, dr... | Methylation & Detox | Strong | |
| rs17309872 | GSS | Downstream regulatory variant of glutathione synthetase (GSS) associated with... | Methylation & Detox | Moderate | |
| rs2066853 | AHR Arg554Lys | Aryl hydrocarbon receptor variant in the transactivation domain that alters A... | Hormones & Sleep | Moderate | |
| rs1799930 | NAT2 R197Q | Slow acetylator variant affecting Phase II detoxification capacity | Methylation & Detox | Established | |
| rs1799983 | NOS3 Glu298Asp | Nitric oxide production - reduced activity increases cardiovascular risk and ... | Methylation & Detox | Established | |
| rs1800566 | NQO1 Pro187Ser (C609T) | Phase II detoxification enzyme that reduces quinones and recycles CoQ10 to it... | Methylation & Detox | Strong | |
| rs1800909 | GGH c.16T>C (p.Cys6Arg) | Signal-peptide missense variant that alters GGH subcellular targeting; C alle... | Methylation & Detox | Moderate | |
| rs662 | PON1 Q192R | Affects paraoxonase-1 enzyme activity for detoxifying organophosphates and pr... | Vascular Inflammation & Remodeling | Moderate | |
| rs1801280 | NAT2 I114T | Phase II detoxification - acetylation of aromatic amines and certain medications | Methylation & Detox | Established | |
| rs61735836 | FTCD | Missense variant in the FTCD enzyme that impairs one-carbon unit transfer fro... | Vitamins & Nutrient Absorption | Strong | |
| rs887829 | UGT1A1 UGT1A1*80 | Promoter variant in UGT1A1 that tags the *28 reduced-expression haplotype; T ... | Vascular Inflammation & Remodeling | Strong | |
| rs2052129 | AOC1 promoter variant | Histamine breakdown in gut - reduced activity means dietary histamine accumul... | Methylation & Detox | Strong | |
| rs2070744 | NOS3 T-786C promoter | NOS3 expression - controls how much eNOS enzyme is produced for nitric oxide ... | Methylation & Detox | Strong | |
| rs7061710 | FMO3 | Intronic FMO3 variant associated with reduced hepatic oxidation of garlic-der... | Vitamins & Nutrient Absorption | Moderate | |
| rs6721961 | NFE2L2 | Promoter variant reducing NRF2 transcriptional activity by >50%, impairing th... | Longevity & Aging | Moderate | |
| rs234706 | CBS C699T | Common synonymous variant in the CBS gene associated with reduced cardiovascu... | Methylation & Detox | Moderate | |
| rs4410790 | AHR | Regulatory variant 54 kb upstream of the aryl hydrocarbon receptor gene; the ... | Hormones & Sleep | Strong | |
| rs366631 | GSTM1 Tag SNP for gene deletion | Tag SNP proxy for GSTM1 gene deletion status — the most common pharmacogenomi... | Methylation & Detox | Strong | |
| rs387907200 | SPR | Missense/splicing variant in sepiapterin reductase that reduces BH4 biosynthe... | Methylation & Detox | Strong | |
| rs2602899 | ADH5 ADH5 Promoter NF-kB Variant | Regulatory SNP in the ADH5 promoter at a potential NF-kB binding site; the pr... | Allergy & Atopic Disease | Moderate | |
| rs4148323 | UGT1A1 *6 Gly71Arg | Phase II glucuronidation enzyme that metabolizes bilirubin and many drugs inc... | Pharmacogenomics | Established | |
| rs2851301 | ADH5 ADH5 Second NF-kB Site Variant | Upstream promoter variant in ADH5 at a potential NF-kB binding site; the mino... | Allergy & Atopic Disease | Emerging | |
| rs4680 | COMT Val158Met | Dopamine/catecholamine breakdown — affects stress response and methyl donor t... | Methylation & Detox | Established | |
| rs28730619 | ADH5 | Intronic variant in ADH5 (GSNOR) associated with elevated childhood asthma ri... | Allergy & Atopic Disease | Moderate | |
| rs4880 | SOD2 Val16Ala | Primary mitochondrial antioxidant enzyme - variant reduces superoxide detoxif... | Methylation & Detox | Strong | |
| rs71748309 | GSTT1 Null (Gene Deletion) | Complete deletion of the GSTT1 gene eliminating glutathione conjugation capac... | Methylation & Detox | Strong | |
| rs819147 | AHCY | Regulatory variant affecting S-adenosylhomocysteine hydrolase expression, inf... | Methylation & Detox | Moderate | |
| rs671 | ALDH2 *2 | Alcohol metabolism - flush reaction and cancer risk | Pharmacogenomics | Established |