Tag
Cognition
32 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs1019385 | GRIN2B | Promoter variant in the GRIN2B Sp1 binding site that reduces NR2B subunit exp... | Neurology & Cognition | Moderate | |
| rs11599236 | SORCS3 SORCS3 Neurotrophin Sorting | Intronic variant in the BDNF-receptor trafficking gene SORCS3, associated wit... | Mood & Behavior | Strong | |
| rs12606138 | NEDD4L | Intronic variant in NEDD4L associated with reading ability and dyslexia susce... | Blood Pressure & Hypertension | Moderate | |
| rs1279683 | SLC23A2 | Intronic variant in the SVCT2 vitamin C transporter — G allele associated wit... | Vitamins & Nutrient Absorption | Moderate | |
| rs1360780 | FKBP5 Intronic C>T | Co-chaperone of the glucocorticoid receptor that regulates cortisol feedback ... | Mood & Behavior | Strong | |
| rs1064395 | NCAN | 3' UTR variant in the neurocan gene associated with bipolar disorder and schi... | Neurology & Cognition | Strong | |
| rs1080985 | CYP2D6 *2A promoter | CYP2D6 promoter variant (-1584C>G) that reduces enzyme expression; the C alle... | Pharmacogenomics | Strong | |
| rs1545843 | SLC6A15 SLC6A15 depression risk variant | Intronic variant reducing SLC6A15 expression in hippocampus; AA carriers show... | Mood & Behavior | Strong | |
| rs1611115 | DBH -1021C>T | Strongest known genetic determinant of dopamine beta-hydroxylase activity, co... | Mood & Behavior | Strong | |
| rs11713169 | NLGN1 | Intronic variant in neuroligin 1, a postsynaptic cell adhesion molecule essen... | Neurology & Cognition | Strong | |
| rs1800497 | DRD2/ANKK1 TaqIA (Glu713Lys) | Reduces dopamine D2 receptor density in the striatum, affecting reward proces... | Mood & Behavior | Strong | |
| rs1800883 | HTR5A | Promoter/5' UTR variant in the serotonin 5-HT5A receptor gene affecting recep... | Mood & Behavior | Moderate | |
| rs1800955 | DRD4 -521C>T | Promoter variant that modulates dopamine D4 receptor expression in the prefro... | Mood & Behavior | Moderate | |
| rs34579341 | NEGR1 NEGR1 Neuronal Growth Regulator | Intronic tag SNP in NEGR1 affecting neuronal cell adhesion, hippocampal neuro... | Mood & Behavior | Strong | |
| rs17070145 | WWC1 Intronic C>T | Influences episodic memory performance and hippocampal function through the K... | Neurology & Cognition | Moderate | |
| rs17518584 | CADM2 | Intronic CADM2 variant genome-wide significant for information processing spe... | Neurology & Cognition | Moderate | |
| rs4149268 | ABCA1 | Intronic ABCA1 variant — the C allele tags a liver enhancer that boosts ABCA1... | Cholesterol & Lipoproteins | Moderate | |
| rs53576 | OXTR Intronic A>G | Most-studied oxytocin receptor variant, influencing empathy, social sensitivi... | Mood & Behavior | Moderate | |
| rs1784931 | SORL1 SORL1 intron 39 variant | Intronic variant in the sortilin-related receptor that tags a 3′ haplotype bl... | Neurology & Cognition | Moderate | |
| rs1906252 | POU3F2 | Regulatory variant at chromosome 6q16.1 near POU3F2 (BRN2), a master transcri... | Neurology & Cognition | Strong | |
| rs73034295 | IGSF9B IGSF9B Inhibitory Synapse Adhesion | Intronic variant in the gene encoding the inhibitory synaptic adhesion protei... | Mood & Behavior | Emerging | |
| rs202676 | FOLH1 T484A | Reduces intestinal folate hydrolase activity, impairing absorption of dietary... | Methylation & Detox | Moderate | |
| rs2274319 | MEF2D | Intronic variant in MEF2D encoding a key neuronal transcription factor that r... | Neurology & Cognition | Strong | |
| rs4307059 | CDH9/CDH10 | Intergenic variant at 5p14.1 between neuronal cell-adhesion genes CDH9 and CD... | Hormones & Sleep | Strong | |
| rs4532 | DRD1 | Regulatory 5'UTR variant in the dopamine D1 receptor gene influencing recepto... | Neurology & Cognition | Moderate | |
| rs4851266 | AFF3 | Intronic variant in the super elongation complex gene AFF3; the T allele incr... | Neurology & Cognition | Strong | |
| rs61734410 | CACNA1H Pro640Leu | Missense variant in CACNA1H encoding the CaV3.2 T-type calcium channel; the L... | Neurology & Cognition | Moderate | |
| rs6265 | BDNF Val66Met | Key neurotrophin variant that controls activity-dependent BDNF release, affec... | Neurology & Cognition | Strong | |
| rs638405 | BACE1 BACE1 Exon 5 Synonymous Variant | Synonymous variant in BACE1 (beta-secretase 1) linked to modestly elevated Al... | Neurology & Cognition | Moderate | |
| rs6439886 | CLSTN2 | Intronic variant in the calsyntenin-2 gene associated with episodic memory pe... | Neurology & Cognition | Moderate | |
| rs6833641 | ARAP2 | Intergenic variant near ARAP2 associated with motion sickness susceptibility ... | Neurology & Cognition | Strong | |
| rs9320913 | POU3F2 | Intergenic regulatory variant upstream of POU3F2 (BRN-2), a transcription fac... | Neurology & Cognition | Strong |