Tag
Carcinogen Metabolism
16 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs1229984 | ADH1B His48Arg | ADH1B variant encoding a ~100x faster alcohol dehydrogenase enzyme, causing r... | Mood & Behavior | Established | |
| rs1693482 | ADH1C Arg272Gln (ADH1C*1/*2) | ADH1C variant defining the fast (ADH1C*1, Arg272) vs slow (ADH1C*2, Gln272) a... | Mood & Behavior | Strong | |
| rs2470890 | CYP1A2 Asn516= (exon 7) | Synonymous variant in CYP1A2 exon 7 in linkage disequilibrium with the *1F hi... | Cancer Risk | Strong | |
| rs28936700 | CYP1B1 Gly61Glu (G61E) | Pathogenic missense variant in the cytochrome P450 1B1 enzyme that abolishes ... | Vascular Inflammation & Remodeling | Established | |
| rs2031920 | CYP2E1 *5B (RsaI) | Promoter variant increasing CYP2E1 inducibility, elevating oxidative stress f... | Pharmacogenomics | Moderate | |
| rs2070672 | CYP2E1 | CYP2E1 promoter variant affecting enzyme expression and susceptibility to ace... | Pharmacogenomics | Moderate | |
| rs28399433 | CYP2A6 *9 (TATA box) | Promoter variant that reduces CYP2A6 expression by ~50%, slowing nicotine met... | Pharmacogenomics | Strong | |
| rs366631 | GSTM1 Tag SNP for gene deletion | Tag SNP proxy for GSTM1 gene deletion status — the most common pharmacogenomi... | Methylation & Detox | Strong | |
| rs4646976 | CYP2E1 | CYP2E1 intronic haplotype tag — affects enzyme activity and susceptibility to... | Pharmacogenomics | Moderate | |
| rs71748309 | GSTT1 Null (Gene Deletion) | Complete deletion of the GSTT1 gene eliminating glutathione conjugation capac... | Methylation & Detox | Strong | |
| rs55897648 | CYP2E1 *3 (Val389Ile) | CYP2E1*3 missense variant with no demonstrated change in enzyme activity for ... | Pharmacogenomics | Emerging | |
| rs6413419 | CYP2E1 *4 (V179I) | Missense variant (Val179Ile) defining the CYP2E1*4 allele; associated with al... | Pharmacogenomics | Emerging | |
| rs72547515 | CYP1A2 *16 (Arg377Gln) | Nearly-inactive CYP1A2 missense variant — carriers have severely impaired met... | Pharmacogenomics | Moderate | |
| rs72547516 | CYP1A2 Ile386Val | Rare CYP1A2 missense variant (Ile386Val) associated with potentially reduced ... | Pharmacogenomics | Emerging | |
| rs72547517 | CYP1A2 *8 | CYP1A2*8 — near-complete loss-of-function missense variant causing severely r... | Pharmacogenomics | Strong | |
| rs8192780 | CYP2E1 | Downstream regulatory variant near CYP2E1 associated with nasopharyngeal carc... | Pharmacogenomics | Emerging |