Tag

Blood Thinners

28 genetic variants with this tag.

RSID	Gene	Description	Category
rs10455872	LPA	Intronic variant strongly associated with elevated lipoprotein(a) levels and ...	Atherogenic Lipoproteins	Blood Thinners	Established
rs1057516616	F11 c.25_28del (p.His9fs)	Frameshift deletion in coagulation factor XI causing complete loss of the FXI...	Coagulation & Clotting Factors	Blood Thinners	Strong
rs121909547	SERPINC1 Arg79Cys	Pathogenic missense variant in the antithrombin III heparin-binding domain; h...	Von Willebrand & Anticoagulant Proteins	Blood Thinners	Established
rs121909548	SERPINC1 Cambridge II (A384S)	Missense variant in antithrombin (SERPINC1) that impairs heparin-catalyzed th...	Von Willebrand & Anticoagulant Proteins	Blood Thinners	Strong
rs121909567	SERPINC1 Budapest 3 (Leu131Phe)	Pathogenic missense in antithrombin III; the A allele causes type II heparin-...	Von Willebrand & Anticoagulant Proteins	Blood Thinners	Established
rs121909569	SERPINC1 Ser148Pro	Likely pathogenic missense variant in antithrombin III; the G allele converts...	Von Willebrand & Anticoagulant Proteins	Blood Thinners	Strong
rs121918473	PROS1 Asn258Ser	Pathogenic PROS1 missense variant in the fourth EGF domain of protein S; hete...	Von Willebrand & Anticoagulant Proteins	Blood Thinners	Strong
rs121918474	PROS1 K196E (Lys196Glu)	Pathogenic missense variant in protein S causing autosomal dominant thromboph...	Von Willebrand & Anticoagulant Proteins	Blood Thinners	Established
rs1799963	F2 G20210A	Second most common inherited thrombophilia; the A allele raises prothrombin l...	Coagulation & Clotting Factors	Blood Thinners	Established
rs121918475	PROS1 Q279X	Pathogenic nonsense variant in protein S that eliminates the anticoagulant co...	Von Willebrand & Anticoagulant Proteins	Blood Thinners	Established
rs1800595	F5 HR2 haplotype (H1299R / R2)	Factor V HR2 haplotype — a missense variant that mildly impairs the anticoagu...	Coagulation & Clotting Factors	Blood Thinners	Moderate
rs1801690	APOH Trp316Ser	Missense variant in APOH (beta-2-glycoprotein I) that disrupts the phospholip...	Atherogenic Lipoproteins	Blood Thinners	Moderate
rs121918476	PROS1 Arg561Trp	Pathogenic PROS1 missense variant in the SHBG-like domain that impairs protei...	Von Willebrand & Anticoagulant Proteins	Blood Thinners	Strong
rs1142345	TPMT *3C	No-function variant causing deficient thiopurine methylation; most common TPM...	Pharmacogenomics	Blood Thinners	Established
rs3798220	LPA Ile4399Met (I4399M)	Missense variant in the protease-like domain of apolipoprotein(a) causing mar...	Atherogenic Lipoproteins	Blood Thinners	Strong
rs2288904	SLC44A2 R154Q	Missense variant that impairs platelet-neutrophil binding and blocks flow-dep...	Von Willebrand & Anticoagulant Proteins	Blood Thinners	Strong
rs369504169	PROC p.Arg42His (c.125G>A)	Rare missense variant in the PROC gene encoding protein C; the A allele subst...	Von Willebrand & Anticoagulant Proteins	Blood Thinners	Strong
rs387906674	PROS1 R355C	Rare pathogenic missense variant in protein S causing hereditary type III pro...	Von Willebrand & Anticoagulant Proteins	Blood Thinners	Strong
rs387906675	PROS1 Y234C	Pathogenic missense variant in the vitamin K-dependent anticoagulant gene PRO...	Von Willebrand & Anticoagulant Proteins	Blood Thinners	Established
rs1800460	TPMT *3B	Decreased-function variant causing reduced thiopurine methylation; pairs with...	Pharmacogenomics	Blood Thinners	Established
rs5186	AGTR1 A1166C	3' UTR variant in angiotensin II type 1 receptor affecting blood pressure reg...	Blood Pressure & Hypertension	Blood Thinners	Moderate
rs1800462	TPMT *2	The original TPMT deficiency allele — a no-function star allele causing ~100-...	Pharmacogenomics	Blood Thinners	Established
rs505922	ABO ABO blood group tag SNP	Tag SNP for the ABO blood group locus; T allele marks blood type O (lower clo...	Coronary Artery Disease & Atherosclerosis	Blood Thinners	Established
rs2108622	CYP4F2 V433M (*3)	Reduces vitamin K metabolism, requiring higher warfarin doses to achieve anti...	Pharmacogenomics	Blood Thinners	Established
rs4244285	CYP2C19 *2	No-function CYP2C19 variant affecting PPIs, clopidogrel, and some antidepress...	Pharmacogenomics	Blood Thinners	Established
rs4986893	CYP2C19 *3	No-function CYP2C19 stop-gain variant — second most common loss-of-function a...	Pharmacogenomics	Blood Thinners	Established
rs6025	F5 Leiden	Factor V Leiden - blood clotting disorder affecting thrombosis risk	Pharmacogenomics	Blood Thinners	Established
rs9923231	VKORC1 -1639G>A	Warfarin sensitivity - determines initial dosing	Pharmacogenomics	Blood Thinners	Established