Tag
Bacterial Sensing
8 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs104895431 | NOD2 | Rare NOD2 missense variant (Ser431Leu) that reduces NF-κB activation in respo... | IBD & Mucosal Immunity | Strong | |
| rs104895467 | NOD2 NOD2 N852S | Rare NOD2 missense variant (Asn852Ser) that impairs innate immune sensing of ... | IBD & Mucosal Immunity | Strong | |
| rs10759931 | TLR4 -2604G>A | Promoter variant in Toll-like receptor 4 that drives higher TLR4 expression a... | Innate Immunity & Infection Defense | Moderate | |
| rs1898830 | TLR2 | Intronic TLR2 variant that modulates innate immune signaling intensity; G all... | Innate Immunity & Infection Defense | Moderate | |
| rs2066844 | NOD2 R702W | Missense variant in the NOD2 gene that increases Crohn's disease risk, partic... | IBD & Mucosal Immunity | Established | |
| rs2066845 | NOD2 G908R | NOD2 bacterial sensor variant that increases Crohn's disease risk by impairin... | IBD & Mucosal Immunity | Established | |
| rs2066847 | NOD2 3020insC (1007fs) | The most important Crohn's disease risk variant worldwide — a frameshift inse... | IBD & Mucosal Immunity | Established | |
| rs3796508 | TLR6 Val327Met | Missense variant substituting valine with methionine at position 327 of TLR6,... | Innate Immunity & Infection Defense | Emerging |