Tag
Appetite
43 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs10150332 | NRXN3 | Obesity and waist circumference GWAS hit in NRXN3 — links reward-circuit syna... | Appetite & Obesity | Strong | |
| rs1042571 | POMC | 3'UTR variant in the appetite-suppression gene POMC that disrupts miRNA bindi... | Appetite & Obesity | Moderate | |
| rs10515237 | PCSK1 PCSK1 A/G (rs10515237) | Intronic variant in PCSK1 that tags the Q665E-S690T functional haplotype, red... | Appetite & Obesity | Moderate | |
| rs1059369 | GDF15 S48T | GDF15 signal-peptide missense variant that tags a haplotype influencing circu... | Fat Storage & Energy | Moderate | |
| rs10766383 | NUCB2 | Intronic NUCB2 variant associated with type 2 diabetes risk in females and or... | Hormones & Sleep | Moderate | |
| rs10767664 | BDNF | Obesity GWAS locus in a conserved BDNF enhancer - reduces hypothalamic BDNF e... | Appetite & Obesity | Strong | |
| rs1137101 | LEPR Q223R (Gln223Arg) | Common leptin receptor variant in the leptin-binding domain affecting satiety... | Hormones & Sleep | Moderate | |
| rs11152221 | MC4R MC4R Proximal LD Block Variant | Intergenic variant in the proximal 3' regulatory block near MC4R associated w... | Appetite & Obesity | Strong | |
| rs11172113 | LRP1 | Intronic enhancer variant in LRP1 that regulates receptor expression in brain... | Fat Storage & Energy | Moderate | |
| rs11644943 | FTO FTO Mid-Gene Intron Variant | An intronic FTO variant outside the well-known intron-1 obesity cluster; the ... | Appetite & Obesity | Emerging | |
| rs12970134 | MC4R MC4R region variant | Near-gene variant ~188kb downstream of MC4R associated with increased waist c... | Appetite & Obesity | Strong | |
| rs13407913 | ADCY3 | Intronic variant in the adenylyl cyclase 3 gene, which encodes a cAMP-produci... | Fitness & Body | Emerging | |
| rs16147 | NPY C-399T | Promoter variant in neuropeptide Y that modulates NPY expression under stress... | Mood & Behavior | Moderate | |
| rs17782313 | MC4R Near-gene C>T | Intergenic variant 188kb downstream of MC4R affecting appetite regulation, me... | Appetite & Obesity | Strong | |
| rs1330 | NUCB2 | Intronic NUCB2 variant associated with obesity risk in males, type 2 diabetes... | Hormones & Sleep | Moderate | |
| rs1800544 | ADRA2A ADRA2A Promoter -1291C>G | Promoter variant that alters alpha-2A adrenergic receptor expression, affecti... | Appetite & Obesity | Moderate | |
| rs1841499 | NEGR1 | Hypothalamic appetite regulator variant linking obesity susceptibility to mig... | Appetite & Obesity | Moderate | |
| rs17219084 | FTO | FTO intron variant in the extended obesity-associated region, with explorator... | Fitness & Body | Emerging | |
| rs1943226 | MC4R MC4R third tagSNP | Upstream regulatory tag variant ~3 kb proximal to MC4R, included in MC4R hapl... | Appetite & Obesity | Emerging | |
| rs2229616 | MC4R V103I | Missense variant in MC4R converting valine to isoleucine at position 103; the... | Appetite & Obesity | Strong | |
| rs2815752 | NEGR1 | Top obesity GWAS variant near NEGR1 — affects hypothalamic appetite regulatio... | Appetite & Obesity | Strong | |
| rs2867125 | TMEM18 TMEM18 regulatory variant (2p25.3) | Regulatory variant at the TMEM18 locus on chromosome 2p25.3 — one of the most... | Appetite & Obesity | Strong | |
| rs2922126 | GHSR GHSR A/G (rs2922126) | Upstream regulatory variant near the ghrelin receptor gene; the A allele is a... | Appetite & Obesity | Moderate | |
| rs29941 | KCTD15 | GWAS obesity locus near KCTD15 — modulates adipogenesis through AP-2 transcri... | Appetite & Obesity | Moderate | |
| rs2568958 | NEGR1 NEGR1 depression/BMI variant | Intergenic tag SNP near NEGR1 associated with elevated BMI and major depressi... | Mood & Behavior | Strong | |
| rs476828 | MC4R MC4R-region BMI variant | Intergenic variant in the MC4R regulatory haplotype block, tagging the same a... | Appetite & Obesity | Strong | |
| rs4788102 | SH2B1 SH2B1/APOBR locus variant | Intronic variant at the SH2B1 locus on chromosome 16p11.2 — a key adaptor pro... | Appetite & Obesity | Strong | |
| rs489693 | MC4R MC4R AIWG variant | Intergenic variant near MC4R with genome-wide significant association with an... | Appetite & Obesity | Strong | |
| rs34579341 | NEGR1 NEGR1 Neuronal Growth Regulator | Intronic tag SNP in NEGR1 affecting neuronal cell adhesion, hippocampal neuro... | Mood & Behavior | Strong | |
| rs490683 | GHSR GHSR Promoter NF-1 Site Variant | Promoter variant in the ghrelin receptor gene that disrupts NF-1 transcriptio... | Appetite & Obesity | Moderate | |
| rs509035 | GHSR GHSR Metabolic Syndrome Variant | Intronic variant in the ghrelin receptor gene; the A allele is associated wit... | Appetite & Obesity | Strong | |
| rs571312 | MC4R MC4R Regulatory Variant (Appetite Signaling) | Regulatory variant upstream of MC4R associated with increased caloric intake,... | Appetite & Obesity | Strong | |
| rs6232 | PCSK1 PCSK1 N221D (Asn221Asp) | Missense variant in PCSK1 encoding an Asn221Asp substitution near the Ca-1 ca... | Appetite & Obesity | Strong | |
| rs6234 | PCSK1 PCSK1 Q665E (Gln665Glu) | Missense variant in PCSK1 that causes a Gln665Glu substitution in the C-termi... | Appetite & Obesity | Strong | |
| rs6235 | PCSK1 PCSK1 S690T (Ser690Thr) | Missense variant encoding the Ser690Thr substitution in the C-terminal domain... | Appetite & Obesity | Strong | |
| rs6548238 | TMEM18 | Second strongest obesity GWAS locus after FTO - influences hypothalamic appet... | Appetite & Obesity | Strong | |
| rs696217 | GHRL Leu72Met | Missense variant in the ghrelin prepropeptide that impairs postprandial ghrel... | Appetite & Obesity | Moderate | |
| rs7647305 | ETV5 | GWAS obesity locus near ETV5 — affects hypothalamic appetite regulation and f... | Appetite & Obesity | Moderate | |
| rs8087522 | MC4R MC4R A/G (rs8087522) | Upstream regulatory variant near MC4R that may create a transcription factor ... | Appetite & Obesity | Emerging | |
| rs9819506 | GHSR GHSR Promoter Variant (Ghrelin Receptor Signaling) | Promoter-region tag SNP in the ghrelin receptor gene associated with body wei... | Appetite & Obesity | Moderate | |
| rs3212018 | CD36 | A 16-bp deletion in the 3' untranslated region of CD36 that may reduce mRNA s... | Triglycerides & Fatty Acids | Emerging | |
| rs9939609 | FTO Intron 1 T>A | The most strongly replicated obesity-associated variant, affecting body weigh... | Appetite & Obesity | Established | |
| rs757081 | NUCB2 Gln338Glu (Q338E) | Missense variant in nucleobindin-2, the precursor protein cleaved to produce ... | Hormones & Sleep | Moderate |