Tag
Addiction
22 genetic variants with this tag.
| RSID | Gene | Description | Category | ||
|---|---|---|---|---|---|
| rs10150332 | NRXN3 | Obesity and waist circumference GWAS hit in NRXN3 — links reward-circuit syna... | Appetite & Obesity | Strong | |
| rs1049353 | CNR1 3'UTR (G1359A) | Synonymous exon 4 variant in the cannabinoid receptor 1 gene; near an exon sp... | Mood & Behavior | Moderate | |
| rs10403955 | CYP2B6 | Intronic CYP2B6 haplotype-tagging variant associated with altered plasma conc... | Pharmacogenomics | Moderate | |
| rs1051730 | CHRNA3 Tyr215Tyr | CHRNA3 synonymous variant in the nicotinic receptor gene cluster strongly ass... | Mood & Behavior | Established | |
| rs1229984 | ADH1B His48Arg | ADH1B variant encoding a ~100x faster alcohol dehydrogenase enzyme, causing r... | Mood & Behavior | Established | |
| rs1693482 | ADH1C Arg272Gln (ADH1C*1/*2) | ADH1C variant defining the fast (ADH1C*1, Arg272) vs slow (ADH1C*2, Gln272) a... | Mood & Behavior | Strong | |
| rs16969968 | CHRNA5 Asp398Asn | Nicotinic receptor variant strongly associated with heavy smoking, nicotine d... | Mood & Behavior | Established | |
| rs1800497 | DRD2/ANKK1 TaqIA (Glu713Lys) | Reduces dopamine D2 receptor density in the striatum, affecting reward proces... | Mood & Behavior | Strong | |
| rs2023239 | CNR1 | Intronic variant near the CNR1 exon 3 alternative promoter that modulates CB1... | Mood & Behavior | Moderate | |
| rs2036527 | CHRNA5/CHRNA3 | Cis-regulatory enhancer variant at 15q25.1 that drives CHRNA3 and CHRNA5 expr... | Mood & Behavior | Strong | |
| rs2066702 | ADH1B Arg370Cys | ADH1B*3 variant encoding a superactive alcohol dehydrogenase found almost exc... | Mood & Behavior | Strong | |
| rs1799971 | OPRM1 A118G | Mu-opioid receptor variant affecting opioid response, pain sensitivity, and p... | Pharmacogenomics | Strong | |
| rs279858 | GABRA2 K132K | GABA-A receptor alpha-2 subunit variant affecting alcohol response, anxiety, ... | Mood & Behavior | Strong | |
| rs1801272 | CYP2A6 *2 (L160H) | Loss-of-function CYP2A6 variant that abolishes nicotine metabolism, slowing c... | Pharmacogenomics | Established | |
| rs324420 | FAAH Pro129Thr | Affects anandamide levels through altered FAAH enzyme stability, influencing ... | Mood & Behavior | Strong | |
| rs578776 | CHRNA3 3' UTR | CHRNA3 3' UTR variant at 15q25.1 Locus 2 — mechanistically distinct from rs10... | Mood & Behavior | Strong | |
| rs588765 | CHRNA5 5' UTR / Locus 3 | Intronic eQTL in CHRNA5 that modulates alpha-5 nicotinic receptor mRNA expres... | Mood & Behavior | Strong | |
| rs6454674 | CNR1 Near gene (SNP3) | Intronic variant in the cannabinoid receptor 1 gene that modulates substance ... | Mood & Behavior | Moderate | |
| rs8034191 | AGPHD1/CHRNA3 15q25.1 intergenic | Intronic variant near CHRNA3 at 15q25.1 that acts as an eQTL for nicotinic re... | Mood & Behavior | Strong | |
| rs806368 | CNR1 | 3'UTR variant in the cannabinoid receptor 1 gene that regulates CB1 expressio... | Mood & Behavior | Moderate | |
| rs3791033 | KDM4A | Intronic variant in KDM4A histone demethylase associated with problematic opi... | Pharmacogenomics | Moderate | |
| rs640561 | LRRIQ3 | Intergenic variant near LRRIQ3 associated with problematic opioid prescriptio... | Pharmacogenomics | Emerging |