Research — GeneOps

rs10038916 — GRIA1

Chromosome 5 Risk Allele G Category Neurology & Cognition Neurotransmitters, Sleep, Arousal, Neurological Risk, Brain Health, Sensory Processing

Intronic variant in the AMPA glutamate receptor gene GRIA1 associated with restless legs syndrome risk via hyperglutamatergic thalamic excitability

rs10050860 — ERAP1 D575N

Chromosome 5 Risk Allele C Category Psoriasis & Spondyloarthropathy Immune System, Autoimmune, MHC Antigen Presentation, Inflammation, Arthritis, Psoriasis

Missense variant (Asp575Asn) in the ERAP1 catalytic domain that modestly reduces peptide trimming efficiency; the protective T allele (Asn575) is co-protective with rs30187 Arg528, with combined homozygous protective state conferring 3-4x lower ankylosing spondylitis risk in HLA-B27-positive individuals

rs10156191 — AOC1 Thr16Met

Chromosome 7 Risk Allele T Category Methylation & Detox Histamine, Food Sensitivity, Detoxification

DAO structural variant affecting enzyme activity and histamine degradation

rs10167914 — IL1A IL1A Endometriosis Susceptibility Variant

Chromosome 2 Risk Allele G Category Endometriosis & Uterine Health Endometriosis, Inflammation, Fertility, Reproductive Health, Women's Health, Chronic Pain

A regulatory tag SNP in the IL1A/IL1B locus on chromosome 2q13; the G allele increases endometriosis risk (OR 1.12) and correlates with elevated IL-1 alpha expression, driving peritoneal inflammation and ectopic lesion establishment.

rs10177833 — SLC4A5

Chromosome 2 Risk Allele A Category Blood Pressure & Hypertension Blood Pressure, Hypertension, Salt Sensitivity, Kidney Function, Cardiovascular, Renal Function

Intronic variant in the sodium bicarbonate cotransporter gene strongly associated with salt-sensitive blood pressure through enhanced renal sodium reabsorption

rs10195252 — GRB14/COBLL1

Chromosome 2 Risk Allele C Category Blood Sugar & Diabetes Fat Metabolism, Insulin, Lipedema, Fat Distribution, Cardiovascular, Women's Health, Diabetes

Intergenic variant between GRB14 and COBLL1 that acts as an eQTL for GRB14 in adipose tissue, shifting body fat toward peripheral (hip and limb) versus central (visceral) deposition

rs10208293 — IL1RL1

Chromosome 2 Risk Allele A Category Allergy & Atopic Disease Asthma, Inflammation, Immune System, Lung Health, Immune & Autoimmune

Intronic IL1RL1 variant tagging an independent regulatory signal at the ST2 locus; A allele increases late-onset wheeze risk and affects sST2 (decoy receptor) expression independently of the primary rs1420101 signal

rs10305492 — GLP1R A316T

Chromosome 6 Risk Allele A Category Pharmacogenomics Drug Metabolism, Diabetes, Insulin, Cardiovascular, Pharmacogenomics

Rare protective missense variant in the GLP-1 receptor associated with lower fasting glucose, reduced T2D risk, and coronary heart disease protection

rs1041981 — LTA Thr26Asn (TNFB*2)

Chromosome 6 Risk Allele A Category Innate Immunity & Infection Defense Innate Immunity, Inflammation, Infection Risk, Cardiovascular, Cancer Risk, Immune Function

Missense variant in lymphotoxin-alpha, a TNF superfamily cytokine essential for secondary lymphoid organ formation and innate immune coordination; the A allele (Asn at position 26 of mature protein) alters LTα trimer stability, modestly increases cancer susceptibility, and has been associated with coronary atherosclerosis and respiratory infection risk

rs1042522 — TP53 Pro72Arg

Chromosome 17 Risk Allele C Category Longevity & Aging Longevity, Aging, Cancer Risk, Antioxidants, Mitochondria

p53 codon 72 polymorphism producing two functionally distinct proteins — Arg72 with stronger apoptotic activity, Pro72 favoring cell cycle arrest and DNA repair — with population data associating Pro/Pro with ~3 years longer median lifespan