Intergenic variant upstream of IFNL3 — second major IL28B locus predictor of hepatitis C spontaneous clearance and treatment response, with independent predictive value over rs12979860 in Asian populations

Intergenic tag SNP between HLA-DQB1 and HLA-DQA2 tagging the HLA-DQA1*01:02 risk haplotype; the C allele confers ~1.7-fold increased susceptibility to peanut allergy and is associated with multiple sclerosis risk

Rare missense variant in microglial receptor TREM2 that significantly increases late-onset Alzheimer's disease risk through impaired microglial function and amyloid clearance

Downstream regulatory variant near CYP2E1 associated with nasopharyngeal carcinoma risk in smokers through altered carcinogen metabolism

Intronic variant in the IL1RL1 gene on chromosome 2q12 encoding the ST2 receptor for IL-33; the T allele is associated with reduced allergic rhinitis risk, particularly in males, by modulating IL-33/ST2 signaling amplitude

GBA missense variant (p.Asn409Ser, formerly N370S) — the most common GBA pathogenic allele; heterozygotes carry substantially elevated risk for Parkinson's disease, Lewy body dementia, and REM sleep behavior disorder; homozygotes develop Gaucher disease type I

A 3' UTR variant in RAD51B that alters miRNA-616 binding efficiency and is associated with increased risk of rheumatoid arthritis and impaired DNA double-strand break repair in immune cells

Warfarin sensitivity - determines initial dosing

Common noncoding variant upstream of LRRK2 that increases gene expression in microglia and Parkinson's disease risk

Regulatory variant upstream of IL33 encoding interleukin-33; the A allele increases IL33 expression in bronchial epithelium and raises risk for asthma, hay fever, and eczema across shared type-2 immune pathways