Upstream promoter variant in ADH5 at a potential NF-kB binding site; the minor T allele is proposed to disrupt NF-kB-driven GSNOR transcription, reducing S-nitrosoglutathione catabolism and providing protection against childhood asthma

Intronic MAPT variant whose A allele defines the H1h sub-haplotype — a configuration distinct from H1c — independently associated with non-tremor dominant Parkinson's disease at OR 2.9 after Bonferroni correction, and sharing no meaningful linkage disequilibrium with the H1c-defining markers rs242557 or rs2471738 (r² ≈ 0.01)

Statin transport - affects muscle side effect risk with statins

Dopamine/catecholamine breakdown — affects stress response and methyl donor tolerance

Multi-allelic pathogenic locus — both H90P (T>G) and H90R (T>C) disrupt the DYRK1B DH box, causing AOMS3 (early-onset central obesity, type 2 diabetes, hypertension, coronary artery disease) via impaired kinase maturation

Intronic TSH quantitative trait locus in phosphodiesterase 8B — the G allele raises the thyroid set-point, increasing hypothyroidism risk and potentially affecting levothyroxine dose requirements

Intronic LIPG variant that tags a haplotype associated with higher LDL cholesterol and apolipoprotein B, with effects on lipid profiles that are substantially modified by physical activity

17q21 regulatory variant in the IKZF3-ORMDL3-GSDMB locus with opposite effects — risk for autoimmune diseases (RA, Crohn's, Graves') but protective for asthma

Variant in the PICALM gene affecting amyloid-beta clearance across the blood-brain barrier and Alzheimer's disease risk

No-function CYP2C19 variant affecting PPIs, clopidogrel, and some antidepressants