3' UTR variant in the ELOVL2 elongase gene that reduces DHA synthesis from its precursor DPA, lowering baseline plasma DHA in C-allele carriers

Missense variant in MTTP (microsomal triglyceride transfer protein) at residue 128; the C allele (Thr128) is associated with reduced hepatic steatosis and lower LDL-cholesterol through a complex, incompletely characterized effect on triglyceride transfer activity

Angiotensinogen level variant affecting blood pressure, sodium sensitivity, and cardiovascular adaptation to exercise

Pathogenic missense variant in ACADM reducing MCAD enzyme activity, predisposing to fatty acid oxidation failure and cardiac stress during fasting, illness, or exercise

Missense variant in the TLR2/TLR4 adaptor protein Mal that modulates innate immune signaling strength, conferring broad infectious disease protection in heterozygous carriers

3' UTR variant in SCARB1 that tags a haplotype with reduced SR-BI expression in the liver, lowering HDL cholesterol and impairing reverse cholesterol transport efficiency

3' UTR variant near miRNA binding sites in MRAS, associated with ~15% increased coronary artery disease risk through altered vascular smooth muscle cell signaling

Intronic tag SNP near HLA-DQA1 that marks the DR3 (DRB1*0301-DQA1*0501-DQB1*0201) haplotype; the T allele tracks the highest-risk HLA genotype for type 1 diabetes and is associated with systemic lupus erythematosus, sarcoidosis, and HLA-mediated immune dysregulation relevant to atopic disease

NOS3 expression - controls how much eNOS enzyme is produced for nitric oxide synthesis

Intronic variant in the alpha-T-catenin gene associated with modestly increased late-onset Alzheimer's disease risk, with the strongest female-specific signal in intron 9 of CTNNA3